Proteins & Peptides

HO2, or heme oxygenase 2, belongs to the heme oxygenase family that are essential enzyme in heme catabolism that cleave heme to form biliverdin which is subsequently converted to bilirubin by biliverdin reductase (1). HO2 is part of the calcium-sensitive potassium channel complex and enhances channel activity in normoxia (2). Knockdown of HO2 expression reduces channel activity, an effect that is reversed by carbon monoxide. Inhibition of calcium-sensitive potassium channels by hypoxia is dependent on HO2 expression and is augmented by HO2 stimulation. HO2 Protein is ideal for investigators involved in Signaling Proteins, Cell Stress & Chaperone Proteins, Cardiovascular Disease, Cellular Stress, and Neurobiology research.

The RAS gene superfamily encodes a group of closely related 21,000 dalton (p21) proteins with special affinity for guanine nucleotides (GTP). RAS and several other cellular proteins with similar biochemical properties are collectively known as G-proteins and they play key roles in a wide variety of cellular activities, including cell growth, differentiation, secretion, and protein trafficking (1). There are three forms of RAS gene in cells termed H-RAS, N-RAS, and K-RAS. RAS proteins play a direct causal role in human cancer and in other diseases. Mutant H-RAS, N-RAS, and K-RAS occur in varying frequencies in different tumor types (2). Other members of the RAS superfamily may also contribute to cancer. HRAS1 (G12V) Protein is ideal to investigators involved in Signaling Proteins, G-Proteins, Apoptosis/Autophagy, Cancer, Cell Cycle, and Ser/Thr Kinase research.

The RAS gene superfamily encodes a group of closely related 21,000 dalton (p21) proteins with special affinity for guanine nucleotides (GTP). RAS and several other cellular proteins with similar biochemical properties are collectively known as G-proteins and they play key roles in a wide variety of cellular activities, including cell growth, differentiation, secretion, and protein trafficking (1). There are three forms of RAS gene in cells termed H-RAS, N-RAS, and K-RAS. RAS proteins play a direct causal role in human cancer and in other diseases. Mutant H-RAS, N-RAS, and K-RAS occur in varying frequencies in different tumor types (2). Other members of the RAS superfamily may also contribute to cancer. HRAS1 (G12V) Protein is ideal for investigators involved in Signaling Proteins, G-Proteins, Apoptosis/Autophagy, Cancer, Cell Cycle, and Ser/Thr Kinase research.

The RAS gene superfamily encodes a group of closely related 21,000 dalton (p21) proteins with special affinity for guanine nucleotides (GTP). RAS and several other cellular proteins with similar biochemical properties are collectively known as G-proteins and they play key roles in a wide variety of cellular activities, including cell growth, differentiation, secretion, and protein trafficking (1). There are three forms of RAS gene in cells termed H-RAS, N-RAS, and K-RAS. RAS proteins play a direct causal role in human cancer and in other diseases. Mutant H-RAS, N-RAS, and K-RAS occur in varying frequencies in different tumor types (2). Other members of the RAS superfamily may also contribute to cancer. HRAS1 (Mature form) Protein is ideal to investigators involved in Signaling Proteins, G-Proteins, Apoptosis/Autophagy, Cancer, Cell Cycle, and Ser/Thr Kinase research.

The RAS gene superfamily encodes a group of closely related 21,000 dalton (p21) proteins with special affinity for guanine nucleotides (GTP). RAS and several other cellular proteins with similar biochemical properties are collectively known as G-proteins and they play key roles in a wide variety of cellular activities, including cell growth, differentiation, secretion, and protein trafficking (1). There are three forms of RAS gene in cells termed H-RAS, N-RAS, and K-RAS. RAS proteins play a direct causal role in human cancer and in other diseases. Mutant H-RAS, N-RAS, and K-RAS occur in varying frequencies in different tumor types (2). Other members of the RAS superfamily may also contribute to cancer. HRAS1 (Mature form) Protein is ideal to investigators involved in Signaling Proteins, G-Proteins, Apoptosis/Autophagy, Cancer, Cell Cycle, and Ser/Thr Kinase research.

HSD17B10 gene encodes the protein 17-beta-hydroxysteroid dehydrogenase 10 that is a member of the short-chain dehydrogenase/reductase superfamily SCHAD (1). HSD17B10 gene product is a mitochondrial protein that is involved in lipid metabolism, fatty acid oxidation and steroid hormone metabolism. HSD17B10 protein has been implicated in the development of Alzheimer's disease and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Furthermore, HSD17B10 may act as a direct molecular link between beta-amyloid and mitochondrial toxicity (2). HSD17B10 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cellular Stress, and Neurobiology research.

HSD17B10 gene encodes the protein 17-beta-hydroxysteroid dehydrogenase 10 that is a member of the short-chain dehydrogenase/reductase superfamily SCHAD (1). HSD17B10 gene product is a mitochondrial protein that is involved in lipid metabolism, fatty acid oxidation and steroid hormone metabolism. HSD17B10 protein has been implicated in the development of Alzheimer's disease and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Furthermore, HSD17B10 may act as a direct molecular link between beta-amyloid and mitochondrial toxicity (2). HSD17B10 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cellular Stress, and Neurobiology research.

HSP10 is a 10-kDa stress-inducible mitochondrial protein which is a member of the heat shock proteins. HSP10 is synthesized at elevated rates in cultured rat hepatoma cells challenged with heat shock or amino acid analogues. HSP10 has been implicated in multiple disease states in humans. In myocardial samples from patients with chronic atrial fibrillation, cardiomyocytes respond to chronic atrial fibrillation with increased expression of HSP10 and HSP60 (1). HSP10 is also overexpressed early in prostate carcinogenesis. HSP10 is also overexpressed in large bowel carcinomas and it may have diagnostic and prognostic significance in the management of this tumour (2). HSP10 Protein is ideal for investigators involved in Signaling Proteins, Cell Stress & Chaperone Proteins, Cardiovascular Disease, and Cellular Stress research.

HSP10 is a 10-kDa stress-inducible mitochondrial protein which is a member of the heat shock proteins. HSP10 is synthesized at elevated rates in cultured rat hepatoma cells challenged with heat shock or amino acid analogues. HSP10 has been implicated in multiple disease states in humans. In myocardial samples from patients with chronic atrial fibrillation, cardiomyocytes respond to chronic atrial fibrillation with increased expression of HSP10 and HSP60 (1). HSP10 is also overexpressed early in prostate carcinogenesis. HSP10 is also overexpressed in large bowel carcinomas and it may have diagnostic and prognostic significance in the management of this tumour (2). HSP10 Protein is ideal for investigators involved in Signaling Proteins, Cell Stress & Chaperone Proteins, Cardiovascular Disease, and Cellular Stress research.