Proteins & Peptides

GRB2 is an adaptor protein that is the homolog of the Sem5 gene of C. elegans and Drk gene of Drosophila. GRB2 protein contains one SH2 domain and two SH3 domains and plays a role in growth factor-mediated signal transduction. GRB2 forms a complex with activated EGFR and the RAS-specific guanine nucleotide exchange factor SOS1 thereby mediating the growth factor-induced activation of RAS (1). GRB2 has been implicated in growth factor regulation of the cytoskeleton and DNA synthesis. DAB2 also binds to GRB2 and competes with SOS for GRB2 binding. GRB2 interacts with the hepatitis C virus nonstructural 5A (NS5A) protein and inhibits the activation of ERK1 and ERK2 by EGF (2). GRB2 Protein is ideal for investigators involved in Signaling Proteins, Adaptor Proteins, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, JAK/STAT Pathway, and Neurobiology research.

GRB2 is an adaptor protein that is the homolog of the Sem5 gene of C. elegans and Drk gene of Drosophila. GRB2 protein contains one SH2 domain and two SH3 domains and plays a role in growth factor-mediated signal transduction. GRB2 forms a complex with activated EGFR and the RAS-specific guanine nucleotide exchange factor SOS1 thereby mediating the growth factor-induced activation of RAS (1). GRB2 has been implicated in growth factor regulation of the cytoskeleton and DNA synthesis. DAB2 also binds to GRB2 and competes with SOS for GRB2 binding. GRB2 interacts with the hepatitis C virus nonstructural 5A (NS5A) protein and inhibits the activation of ERK1 and ERK2 by EGF (2). GRB2 Protein is ideal for investigators involved in Signaling Proteins, Adaptor Proteins, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, JAK/STAT Pathway, and Neurobiology research.

GRB7 or growth factor receptor-bound protein 7 belongs to a small family of adapter proteins which interact with a number of receptor tyrosine kinases and signaling molecules. GRB7 encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. GRB7 is highly expressed in liver and kidney (1). GRB7 isoforms are involved in cell invasion and metastatic progression of human esophageal carcinomas (2). GRB7 plays an important role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). GRB7 Protein is ideal for investigators involved in Signaling Proteins, Adaptor Proteins, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, JAK/STAT Pathway, and Neurobiology research.

GRB7 or growth factor receptor-bound protein 7 belongs to a small family of adapter proteins which interact with a number of receptor tyrosine kinases and signaling molecules. GRB7 encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. GRB7 is highly expressed in liver and kidney (1). GRB7 isoforms are involved in cell invasion and metastatic progression of human esophageal carcinomas (2). GRB7 plays an important role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). GRB7 Protein is ideal for investigators involved in Signaling Proteins, Adaptor Proteins, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, JAK/STAT Pathway, and Neurobiology research.

HERC4 or HECT and RLD domain containing E3 ubiquitin protein ligase 4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD domain is predicted to act as a guanine nucleotide exchange factor for small G proteins (1). HERC4 is highly expressed in adult and fetal brain and in all specific brain regions examined (2). HERC4 Protein is ideal for investigators involved in Signaling Proteins, Ubiquitin Proteins, Cancer, Cell Cycle, Cytoplasmic Tyrosine Kinases, and Neurobiology research.

HERC4 or HECT and RLD domain containing E3 ubiquitin protein ligase 4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD domain is predicted to act as a guanine nucleotide exchange factor for small G proteins (1). HERC4 is highly expressed in adult and fetal brain and in all specific brain regions examined (2). HERC4 Protein is ideal for investigators involved in Signaling Proteins, Ubiquitin Proteins, Cancer, Cell Cycle, Cytoplasmic Tyrosine Kinases, and Neurobiology research.

HO1 (Heme oxygenase 1) catalyzes the oxidative cleavage of heme to biliverdin and is one of the main genes controlling heme synthesis and catabolism. HO1 plays a protective role in various disorders and can ameliorate experimental MN via multiple pathways, including anti-oxidative and immunomodulatory effects (1). Exposure of primary hepatocytes to carbon monoxide and nitric oxide results in dramatic induction of HO1 in dose- and time-dependent manner and this induction is blocked by MAP kinase inhibitors (MAPKs) but not by inhibitors of PI3 kinase pathway (2). HO1 Protein is ideal for investigators involved in Signaling Proteins, Cell Stress & Chaperone Proteins, Cancer, Cardiovascular Disease, Cellular Stress, Inflammation, and Neurobiology research.

HO1 (Heme oxygenase 1) catalyzes the oxidative cleavage of heme to biliverdin and is one of the main genes controlling heme synthesis and catabolism. HO1 plays a protective role in various disorders and can ameliorate experimental MN via multiple pathways, including anti-oxidative and immunomodulatory effects (1). Exposure of primary hepatocytes to carbon monoxide and nitric oxide results in dramatic induction of HO1 in dose- and time-dependent manner and this induction is blocked by MAP kinase inhibitors (MAPKs) but not by inhibitors of PI3 kinase pathway (2). HO1 Protein is ideal for investigators involved in Signaling Proteins, Cell Stress & Chaperone Proteins, Cancer, Cardiovascular Disease, Cellular Stress, Inflammation, and Neurobiology research.

HO2, or heme oxygenase 2, belongs to the heme oxygenase family that are essential enzyme in heme catabolism that cleave heme to form biliverdin which is subsequently converted to bilirubin by biliverdin reductase (1). HO2 is part of the calcium-sensitive potassium channel complex and enhances channel activity in normoxia (2). Knockdown of HO2 expression reduces channel activity, an effect that is reversed by carbon monoxide. Inhibition of calcium-sensitive potassium channels by hypoxia is dependent on HO2 expression and is augmented by HO2 stimulation. HO2 Protein is ideal for investigators involved in Signaling Proteins, Cell Stress & Chaperone Proteins, Cardiovascular Disease, Cellular Stress, and Neurobiology research.