Proteins & Peptides

Parathyroid hormone (pTH) is the most important endocrine regulator of Ca2+ and phosphorus concentration in the extracellular fluid. pTH is secreted from cells of the parathyroid glands and acts for the most part via the binding to specific G-protein coupled receptors on the surface of  target cells in bone and kidney, utilizing the second messenger adenylate cyclase to regulate cAMP levels in cells.  Like most other protein hormones, parathyroid hormone is synthesized as a preprohormone and is processed intracellularly.  The mature hormone, 84 amino acids in length, is released from secretory vesicles into the blood.  Biologic effects of large C-terminal parathyroid hormone (PTH) fragments, such as pTH 7-84, are thought to regulate PTH secretion via an autocrine/paracrine regulatory mechanism

Parathyroid hormone (pTH) is the most important endocrine regulator of Ca2+ and phosphorus concentration in the extracellular fluid. pTH is secreted from cells of the parathyroid glands and acts for the most part via the binding to specific G-protein coupled receptors on the surface of  target cells in bone and kidney, utilizing the second messenger adenylate cyclase to regulate cAMP levels in cells.  Like most other protein hormones, parathyroid hormone is synthesized as a preprohormone and is processed intracellularly.  The mature hormone, 84 amino acids in length, is released from secretory vesicles into the blood.  Biologic effects of large C-terminal parathyroid hormone (PTH) fragments, such as pTH 7-84, are thought to regulate PTH secretion via an autocrine/paracrine regulatory mechanism

Parathyroid hormone (pTH) is the most important endocrine regulator of Ca2+ and phosphorus concentration in the extracellular fluid. pTH is secreted from cells of the parathyroid glands and acts for the most part via the binding to specific G-protein coupled receptors on the surface of  target cells in bone and kidney, utilizing the second messenger adenylate cyclase to regulate cAMP levels in cells.  Like most other protein hormones, parathyroid hormone is synthesized as a preprohormone and is processed intracellularly.  The mature hormone, 84 amino acids in length, is released from secretory vesicles into the blood.  Biologic effects of large C-terminal parathyroid hormone (PTH) fragments, such as pTH 7-84, are thought to regulate PTH secretion via an autocrine/paracrine regulatory mechanism

Parathyroid hormone (pTH) is the most important endocrine regulator of Ca2+ and phosphorus concentration in the extracellular fluid. pTH is secreted from cells of the parathyroid glands and acts for the most part via the binding to specific G-protein coupled receptors on the surface of  target cells in bone and kidney, utilizing the second messenger adenylate cyclase to regulate cAMP levels in cells.  Like most other protein hormones, parathyroid hormone is synthesized as a preprohormone and is processed intracellularly.  The mature hormone, 84 amino acids in length, is released from secretory vesicles into the blood.  Biologic effects of large C-terminal parathyroid hormone (PTH) fragments, such as pTH 7-84, are thought to regulate PTH secretion via an autocrine/paracrine regulatory mechanism

Parathyroid hormone (pTH) is the most important endocrine regulator of Ca2+ and phosphorus concentration in the extracellular fluid. pTH is secreted from cells of the parathyroid glands and acts for the most part via the binding to specific G-protein coupled receptors on the surface of  target cells in bone and kidney, utilizing the second messenger adenylate cyclase to regulate cAMP levels in cells.  Like most other protein hormones, parathyroid hormone is synthesized as a preprohormone and is processed intracellularly.  The mature hormone, 84 amino acids in length, is released from secretory vesicles into the blood.  Biologic effects of large C-terminal parathyroid hormone (PTH) fragments, such as pTH 7-84, are thought to regulate PTH secretion via an autocrine/paracrine regulatory mechanism

Cathelicidin (LL-37) are a family of antimicrobial proteins found in lysosomes of macrophages and polymorphonuclear leukocytes. Along with the family of proteins known as defensins, cathelicidins participate in the first line of defense by preventing local infection and systemic invasion of microbes. LL-37 binds to bacterial lipopolysaccharides (LPS) and is a potent chemotactic factor for recruiting mast cells to sites of inflammation. LL-37 is present in inflammatory skin diseases that include psoriasis, sub-acute lupus erthematosus, dermatitis and nickel contact hypersensitivity. It is not found in normal skin epidermis. The secreted protein is expressed primarily in bone marrow, testis and neutrophils.

Cathelicidin (LL-37) are a family of antimicrobial proteins found in lysosomes of macrophages and polymorphonuclear leukocytes. Along with the family of proteins known as defensins, cathelicidins participate in the first line of defense by preventing local infection and systemic invasion of microbes. LL-37 binds to bacterial lipopolysaccharides (LPS) and is a potent chemotactic factor for recruiting mast cells to sites of inflammation. LL-37 is present in inflammatory skin diseases that include psoriasis, sub-acute lupus erthematosus, dermatitis and nickel contact hypersensitivity. It is not found in normal skin epidermis. The secreted protein is expressed primarily in bone marrow, testis and neutrophils.

Cathelicidin (LL-37) are a family of antimicrobial proteins found in lysosomes of macrophages and polymorphonuclear leukocytes. Along with the family of proteins known as defensins, cathelicidins participate in the first line of defense by preventing local infection and systemic invasion of microbes. LL-37 binds to bacterial lipopolysaccharides (LPS) and is a potent chemotactic factor for recruiting mast cells to sites of inflammation. LL-37 is present in inflammatory skin diseases that include psoriasis, sub-acute lupus erthematosus, dermatitis and nickel contact hypersensitivity. It is not found in normal skin epidermis. The secreted protein is expressed primarily in bone marrow, testis and neutrophils.

LL-37 is a cleaved antimicrobial residue peptide of hCAP18 (human cationic antimicrobial protein, 18kDa) in the family of cathelicidin. Cathelicidins are predominantly found in the peroxidase negative granules of neutrophils. And it has been shows broad antimicrobial activity towards gram negative and gram positive bacteria.