Proteins & Peptides

N6AMT2 is a putative DNA methyltransferase, belongs to the methyltransferase superfamily, AML1 family. The N6AMT2 gene is conserved in human, mouse, rat, chimpanzee, dog, cow, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, N.crassa, A.thaliana, and rice (1). The N6AMT2 phosphorylation at Ser-2 has been reported (2). The function of this protein has not been widely studied yet. N6AMT2 Protein is ideal to investigators involved in Signaling Proteins, Acetyl/Methyltransferase Proteins, Apoptosis/Autophagy, Cancer, Cell Cycle, and Neurobiology research.

NCK (or non-catalytic region of tyrosine kinase adaptor protein 1) is an adaptor protein that is located in the cytoplasm and involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS (1). NCK is a signaling and transforming protein that contains Src homology 2 and 3 (SH2 and SH3) domains. NCK functions by coupling tyrosine phosphorylation via SH2 domains to downstream effectors through SH3 domains. Furthermore, NCK couples tyrosine phosphorylation guidance signals to cytoskeletal events required for the ipsilateral projections of spinal cord neurons and for normal limb movement (2). NCK Protein is ideal for investigators involved in Signaling Proteins, Adaptor Proteins, Angiogenesis, Cancer, Inflammation, and Invasion/Metastasis research.

NCK (or non-catalytic region of tyrosine kinase adaptor protein 1) is an adaptor protein that is located in the cytoplasm and involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS (1). NCK is a signaling and transforming protein that contains Src homology 2 and 3 (SH2 and SH3) domains. NCK functions by coupling tyrosine phosphorylation via SH2 domains to downstream effectors through SH3 domains. Furthermore, NCK couples tyrosine phosphorylation guidance signals to cytoskeletal events required for the ipsilateral projections of spinal cord neurons and for normal limb movement (2). NCK Protein is ideal for investigators involved in Signaling Proteins, Adaptor Proteins, Angiogenesis, Cancer, Inflammation, and Invasion/Metastasis research.

NFATC1 is a member of the NFAT family of proteins which are Ca2+/calcineurin-responsive transcription factors primarily recognized for their central roles in T lymphocyte activation and cardiac valve development (1). NFAT consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T-cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to the NFAT family of transcription factors play a central role in inducible gene transcription during immune response. The product of NFATC1 is an inducible nuclear component and functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A (2). NFATC1 Protein is ideal for investigators involved in Signaling Proteins, Transcription Proteins, Cardiovascular Disease, Inflammation, JNK/SAPK Pathway, NfkB Pathway, and p38 Pathway research.

NFATC1 is a member of the NFAT family of proteins which are Ca2+/calcineurin-responsive transcription factors primarily recognized for their central roles in T lymphocyte activation and cardiac valve development (1). NFAT consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T-cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to the NFAT family of transcription factors play a central role in inducible gene transcription during immune response. The product of NFATC1 is an inducible nuclear component and functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A (2). NFATC1 Protein is ideal for investigators involved in Signaling Proteins, Transcription Proteins, Cardiovascular Disease, Inflammation, JNK/SAPK Pathway, NfkB Pathway, and p38 Pathway research.

NFKB2 is a part of the NFKB complex that is present in various cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and disease states. NFKB protein is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products (1). Inappropriate activation of NFKB has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS (2). Overexpression of NFKB2 protects androgen sensitive LNCaP cells from apoptotic cell death and cell cycle arrest induced by androgen-deprivation. NFKB2 Protein is ideal for investigators involved in Signaling Proteins, Transcription Proteins, AKT/PKB Pathway, Apoptosis/Autophagy, Inflammation, and p38 Pathway research.

NFKB2 is a part of the NFKB complex that is present in various cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and disease states. NFKB protein is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products (1). Inappropriate activation of NFKB has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS (2). Overexpression of NFKB2 protects androgen sensitive LNCaP cells from apoptotic cell death and cell cycle arrest induced by androgen-deprivation. NFKB2 Protein is ideal for investigators involved in Signaling Proteins, Transcription Proteins, AKT/PKB Pathway, Apoptosis/Autophagy, Inflammation, and p38 Pathway research.

OSR1 is a member of the Ser/Thr family of protein kinases. OSR1 is activated by osmotic stresses and regulates the downstream protein kinase such as PAK1 in order to establish the sensor/signaling modules that initiate the cellular response to environmental stress (1). OSR1 can be phosphorylated by ATM or ATR during DNA damage process (2). OSR1 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cardiovascular Disease, and Ser/Thr Kinases research.

OSR1 is a member of the Ser/Thr family of protein kinases. OSR1 is activated by osmotic stresses and regulates the downstream protein kinase such as PAK1 in order to establish the sensor/signaling modules that initiate the cellular response to environmental stress (1). OSR1 can be phosphorylated by ATM or ATR during DNA damage process (2). OSR1 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cardiovascular Disease, and Ser/Thr Kinases research.