Proteins & Peptides

CDC2L1 is a member of the p34Cdc2 protein kinase family. p34Cdc2 protein kinase family is known to be essential for eukaryotic cell cycle control. CDC2L1 is well conserved evolutionarily and is regulated during murine embryogenesis. CDC2L1 activity is coordinately regulated with that of p34 (cdc2) during the cell cycle (1). The protein kinase encoded by CDC2L1 can be cleaved by caspases and is demonstrated to play roles in cell apoptosis (2). CDC2L1 Protein is ideal for investigators involved in Signaling Proteins, Cell Cylce Proteins, Cancer, Cell Cycle, and Ser/Thr Kinases research.

CDK2 is a member of the Cyclin-Dependent Kinase family that is ubiquitously expressed. CDK2 is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. CDK2 associates with and is regulated by the regulatory subunits of the complex including Cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B) (1). CDK2 phosphorylates multiple cellular substrates including SMAD3 and FOXO1. Phosphorylation of FOXO1 leads to its inhibition (2). CDK2 Protein is ideal for investigators involved in Signaling Proteins, Cell Cycle Proteins, Cancer, Cell Cycle, and Ser/Thr Kinases research.

CDK2 is a member of the Cyclin-Dependent Kinase family that is ubiquitously expressed. CDK2 is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. CDK2 associates with and is regulated by the regulatory subunits of the complex including Cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B) (1). CDK2 phosphorylates multiple cellular substrates including SMAD3 and FOXO1. Phosphorylation of FOXO1 leads to its inhibition (2). CDK2 Protein is ideal for investigators involved in Signaling Proteins, Cell Cycle Proteins, Cancer, Cell Cycle, and Ser/Thr Kinases research.

CDK5P25 (cyclin-dependent kinase 5, regulatory subunit 1) is a neuron-specific activator of CDK5 and is required for proper development of the central nervous system (1). The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form of the protein which relocates from the cell periphery to nuclear and perinuclear regions. CDK5P25 regulates CDK5 activity by prolonging its activation and changing its cellular location and this may be important in pain signaling (2). The CDK5P25 accumulates in the brain neurons of patients with Alzheimer's disease and this accumulation correlates with an increase in CDK5 kinase activity which may result in aberrantly phosphorylated forms of the microtubule-associated protein tau. CDK5P25 Protein is ideal for investigators involved in Signaling Proteins, Cell Cycle Proteins, Cancer, Cell Cycle, and Ser/Thr Kinases research.

CDK5P25 (cyclin-dependent kinase 5, regulatory subunit 1) is a neuron-specific activator of CDK5 and is required for proper development of the central nervous system (1). The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form of the protein which relocates from the cell periphery to nuclear and perinuclear regions. CDK5P25 regulates CDK5 activity by prolonging its activation and changing its cellular location and this may be important in pain signaling (2). The CDK5P25 accumulates in the brain neurons of patients with Alzheimer's disease and this accumulation correlates with an increase in CDK5 kinase activity which may result in aberrantly phosphorylated forms of the microtubule-associated protein tau. CDK5P25 Protein is ideal for investigators involved in Signaling Proteins, Cell Cycle Proteins, Cancer, Cell Cycle, and Ser/Thr Kinases research.

CDK5P35 is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5) that bind to cyclin to form active holoenzymes that play a pivotal role in the regulation of the eukaryotic cell cycle .The activation of CDK5 is required for proper development of the central nervous system. p35 is a regulatory subunit for CDK5 which is proteolytically cleaved by calpain and generating a p25 form that involved in the pathogenesis of cytoskeletal abnormalities and neuronal death in neurodegenerative diseases (1). Cdk/p35 plays a role in primary afferent nociceptive signaling and is required for cortical plate neurons to migrate past preexisting neurons and take up superficial positions to constitute the inside-outside layering order of cortical lamination(2). CDK5P35 Protein is ideal for investigators involved in Signaling Proteins, Cell Cycle Proteins, Cancer, Cell Cycle, and Ser/Thr Kinases research.

CDK5P35 is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5) that bind to cyclin to form active holoenzymes that play a pivotal role in the regulation of the eukaryotic cell cycle .The activation of CDK5 is required for proper development of the central nervous system. p35 is a regulatory subunit for CDK5 which is proteolytically cleaved by calpain and generating a p25 form that involved in the pathogenesis of cytoskeletal abnormalities and neuronal death in neurodegenerative diseases (1). Cdk/p35 plays a role in primary afferent nociceptive signaling and is required for cortical plate neurons to migrate past preexisting neurons and take up superficial positions to constitute the inside-outside layering order of cortical lamination(2). CDK5P35 Protein is ideal for investigators involved in Signaling Proteins, Cell Cycle Proteins, Cancer, Cell Cycle, and Ser/Thr Kinases research.

CDKL1 or cyclin-dependent kinase-like 1 is a member of a large family of CDC2-related serine/threonine protein kinases. CDKL1, which is also known as p42 KKIALRE, accumulates primarily in the nucleus and is known to regulate important transitions in the eukaryotic cell cycle (1). CDKL1 and the related CDC2 protein kinase have a similar pattern of mRNA expression except in the reproductive organs. CDKL1 is expressed in several human tissues, with the highest expression in kidney and ovary (2). CDKL1 is overexpressed in breast cancer patients and has a positive detection efficiency of 77%. Inhibiting CDKL1 function with shRNA in MCF-7 cells shows increased accumulation of the cells at the G2/M phase and increased sensitivity to cell cycle chemotherapeutic drugs. CDKL1 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cancer, Cell Cycle, and Ser/Thr Kinases research.

CDKL1 or cyclin-dependent kinase-like 1 is a member of a large family of CDC2-related serine/threonine protein kinases. CDKL1, which is also known as p42 KKIALRE, accumulates primarily in the nucleus and is known to regulate important transitions in the eukaryotic cell cycle (1). CDKL1 and the related CDC2 protein kinase have a similar pattern of mRNA expression except in the reproductive organs. CDKL1 is expressed in several human tissues, with the highest expression in kidney and ovary (2). CDKL1 is overexpressed in breast cancer patients and has a positive detection efficiency of 77%. Inhibiting CDKL1 function with shRNA in MCF-7 cells shows increased accumulation of the cells at the G2/M phase and increased sensitivity to cell cycle chemotherapeutic drugs. CDKL1 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cancer, Cell Cycle, and Ser/Thr Kinases research.