Proteins & Peptides

Fractalkine, also known as CX3CL1, is an atypical chemokine that was the first of a fourth chemokine motif (CX3C). It is thought to function as a T cell and monocyte chemotractant and is produced by non-haemopoietic cells. Fractalkine is made in a soluble and membrane bound form in activated endothelial cells which is thought to promote adhesion of leukocytes. Recombinant human Fractalkine is a non-glycosylated protein, containing 76 amino acids, with a molecular weight of 8.6 kDa.

IKKgamma is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. IKKgamma forms dimers and trimers and interacts preferentially with IKKbeta but not IKKalpha (1). IKKgamma associates with activated ATM after the induction of DNA double-strand breaks (2). ATM phosphorylates serine-85 of IKKgamma to promote its ubiquitin-dependent nuclear export. IKKgamma Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cancer, Inflammation, Neurobiology, Ser/Thr Kinases, and WNT Signaling research.

IKKgamma is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. IKKgamma forms dimers and trimers and interacts preferentially with IKKbeta but not IKKalpha (1). IKKgamma associates with activated ATM after the induction of DNA double-strand breaks (2). ATM phosphorylates serine-85 of IKKgamma to promote its ubiquitin-dependent nuclear export. IKKgamma Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cancer, Inflammation, Neurobiology, Ser/Thr Kinases, and WNT Signaling research.

TRAF2 (also known as TNF receptor-associated factor 2) belongs to the TNF receptor associated factor (TRAF) protein family that mediates signal transduction from members of the TNF receptor superfamily (1). TRAF2 is involved in TNF-alpha-mediated activation of MAPK8/JNK and NF-kB pathway. TRAF2 interacts with TNF receptors and forms a heterodimeric complex with TRAF1. The TRAF1-TRAF2 complex interacts with IAPs to mediate the anti-apoptotic signals from TNF receptors. TRAF2 also interacts with TRADD, a TNF receptor associated apoptotic signal transducer, to ensure the recruitment of IAPs for the direct inhibition of caspase activation (2). TRAF2 Protein is ideal for investigators involved in Signaling Proteins, Adaptor Proteins, Apoptosis/Autophagy, Cancer, Inflammation, JNK/SAPK Pathway, and NfkB Pathway research.

TRAF2 (also known as TNF receptor-associated factor 2) belongs to the TNF receptor associated factor (TRAF) protein family that mediates signal transduction from members of the TNF receptor superfamily (1). TRAF2 is involved in TNF-alpha-mediated activation of MAPK8/JNK and NF-kB pathway. TRAF2 interacts with TNF receptors and forms a heterodimeric complex with TRAF1. The TRAF1-TRAF2 complex interacts with IAPs to mediate the anti-apoptotic signals from TNF receptors. TRAF2 also interacts with TRADD, a TNF receptor associated apoptotic signal transducer, to ensure the recruitment of IAPs for the direct inhibition of caspase activation (2). TRAF2 Protein is ideal for investigators involved in Signaling Proteins, Adaptor Proteins, Apoptosis/Autophagy, Cancer, Inflammation, JNK/SAPK Pathway, and NfkB Pathway research.

AKT1 is a component of the PI-3 kinase pathway and is activated by phosphorylation at Ser 473 and Thr 308. AKT is a cytoplasmic protein also known as Protein Kinase B (PKB) and RAC (Related to A and C kinases). AKT is a key regulator of many signal transduction pathways, and it exhibits tight control over cell proliferation and cell viability. Overexpression or inappropriate activation of AKT is noted in many types of cancer. AKT mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. AKT has two main roles: (i) inhibition of apoptosis; (ii) promotion of proliferation. AKT1 recombinant protein is ideal for investigators involved in Cell Signaling, Neuroscience and Signal Transduction research.

Interleukin-22 (IL-22), also called IL-TIF, is an IL-10 family member, produced by activated dendritic cells and T lymphocytes. IL-22 signals via the IL-22R and IL-10Rbeta receptors to act as a potent mediator of the cellular inflammatory response. Recombinant human IL-22 is a non-disulfide-linked homodimer, containing two 146 amino acids, with a total molecular weight of 33.6 kDa.

Interleukin-22 (IL-22), also called IL-TIF, is an IL-10 family member, produced by activated dendritic cells and T lymphocytes. IL-22 signals via the IL-22R and IL-10Rbeta receptors to act as a potent mediator of the cellular inflammatory response. Recombinant human IL-22 is a non-disulfide-linked homodimer, containing two 146 amino acids, with a total molecular weight of 33.6 kDa.

Interleukin-22 (IL-22), also called IL-TIF, is an IL-10 family member, produced by activated dendritic cells and T lymphocytes. IL-22 signals via the IL-22R and IL-10Rbeta receptors to act as a potent mediator of the cellular inflammatory response. Recombinant human IL-22 is a non-disulfide-linked homodimer, containing two 146 amino acids, with a total molecular weight of 33.6 kDa.