Proteins & Peptides

Human Angiotensin converting enzyme 2 (ACE2) also known ACEH, GenBank Accession No. NP_068576.1, a.a. 18-740, with a C-terminal His-tag, expressed in a HEK293 expression system. MW=85 kDa.

Please note this product may be subject to fees, we invite you to contact your local office. Human DNA polymerase β (beta), also known as Pol beta and POLB (GenBank Accession No. NM_002690), a.a. 2-335 (end), with N-terminal His-tag, MW=39 kDa, expressed in an E. coli cell expression system.

Human DNA polymerase ? (beta), also known as Pol beta and POLB (GenBank Accession No. NM_002690), a.a. 2-335 (end), with N-terminal His-tag, MW=39 kDa, expressed in an E. coli cell expression system.

ND-630 (NDI 010976) is a highly specific, reversible inhibitor of ACC1 (IC50 = 2 nM) and ACC2 (IC50 = 6 nM). ND-630 interacts within the ACC phosphopeptide acceptor and dimerization site to prevent dimerization of ACC. Because the dimerization site is not conserved among other mammalian carboxylases, ND-630 lacks the ability to inhibit other mechanistically-related enzymes. In rats with diet-induced obesity, ND-630 reduced hepatic steatosis, improved insulin sensitivity, and reduced weight gain, suggesting ACC inhibition may be useful in treating metabolic disorders, including type 2 diabetes mellitus, and fatty liver disease.

ND-630 (NDI 010976) is a highly specific, reversible inhibitor of ACC1 (IC50 = 2 nM) and ACC2 (IC50 = 6 nM). ND-630 interacts within the ACC phosphopeptide acceptor and dimerization site to prevent dimerization of ACC. Because the dimerization site is not conserved among other mammalian carboxylases, ND-630 lacks the ability to inhibit other mechanistically-related enzymes. In rats with diet-induced obesity, ND-630 reduced hepatic steatosis, improved insulin sensitivity, and reduced weight gain, suggesting ACC inhibition may be useful in treating metabolic disorders, including type 2 diabetes mellitus, and fatty liver disease.

Synthetic peptide corresponding to a.a. 107-122 of Histone-H2A, MW= 1762.1.

Synthetic peptide corresponding to a.a. 107-122 of Histone-H2A, MW= 1762.1.