Nucleic Acids

1-[(5E)-3-O-[(Bis-diiPr-amino)(2-cyano ethoxy)phosphino]-5,6-dideoxy-6-(diethoxy phosphinyl)-2-O-(2-MeO-Et)-?-D-ribo-hex-5-enofuranosyl]uracil, containing a 2'-O-MOE-modified uridine nucleoside, can be used to form antisense RNA. The 2'-MOE backbone enhances duplex stability and nuclease protection.

DMTr-LNA-5MeC(Bz)-3-CED-phosphoramidite is a Locked Nucleic Acid (LNA) phosphoramidite, which is a bicyclic amidite where a ribonucleoside is linked between the 2’-oxygen and the 4’-carbon atoms with a methylene unit. This amidite is integral to Locked Nucleic Acid (LNA) oligonucleotide synthesis, following a parallel process to DNA polymers.

DMTr-LNA-5MeU-3-CED-phosphoramidite is vital for Locked Nucleic Acid (LNA) oligonucleotide synthesis, which features a ribonucleoside connected by a methylene unit between 2’-oxygen and 4’-carbon atoms, mirroring DNA polymerization in structure and process.

DMTr-LNA-U-3-CED-phosphoramidite is a component essential to Locked Nucleic Acid (LNA) oligonucleotide synthesis, which entails the incorporation of a ribonucleoside linked by a methylene unit between the 2’-oxygen and 4’-carbon atoms, mirroring DNA polymerization.

3'-O-MOE-A(Bz)-2'-CED-phosphoramidite is a phosphoramidite monomer for crafting unique oligonucleotides or modified RNA derivatives.

3'-F-3'-dA(Bz)-2'-phosphoramidite is a modified adenine phosphoramidite with a fluorine at the 3' position and capped by a benzoyl functional group. It can be used to synthesize DNA.

2'-O-MOE-C(Bz)-3'-phosphoramidite inserts a 2'-O-MOE-modified cytidine into oligonucleotide phosphoramidites for antisense RNA. Its 2'-MOE backbone bolsters duplex stability, nuclease resistance, and has low toxicity, contributing to effective, safe genetic manipulation.

2'-Deoxy-5'-O-DMT-N6-Fmoc-adenosine 3'CE-phosphoramidite is a prized asset in biomedical research that empowers tailored nucleic acid designs and integrates N6-Fmoc-adenosine variations for intricate exploration of modified nucleic acids and their interactions with proteins/enzymes.

5'-O-DMTr-N4-Fmoc-5-Me-dC-phosphoramidite is a cytidine amidite analog containing a Fmoc protecting group and a methyl group on the 5' position of the base.