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Beta-1-Methylpseudouridine is a substitute for uridine in modified mRNA and has been shown to increase transfection by reducing immuogenicity. Beta-1-Methylpseudouridine substituted mRNA increases protein expression due to low immune stimulation as it evades detection by the edosomal Toll-like receptor (TLR3). Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.