Nucleic Acids

2-Aminoadenosine is a nucleoside analog that is used as a substrate for the enzyme adenosine deaminase. 2-Aminoadenosine inhibits the growth of certain cancer cells by inhibiting the activity of DNA polymerase and RNA polymerase. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-Deoxyadenosine monohydrate is an adenosine nucleotide, which can be synthesized by the enzyme adenosine kinase. 2'-Deoxyadenosine monohydrate is a competitive inhibitor of phosphodiesterase, which breaks down cyclic nucleotides to their corresponding monophosphate form. This leads to elevated levels of cAMP, which can cause neuronal death by apoptosis. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

4-Methylumbelliferyl-beta-D-glucuronide is a fluorescent substrate of beta-glucuronidase. Once cleaved, 4-Methylumbelliferyl-beta-D-glucuronide yields blue fluorescence seen under UV light which is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively. It is ideal for working with Escherichia coli and plant molecular studies. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

5'-O-(tert-Butyldimethylsilyl)thymidine is a synthetic nucleoside that is used as an antiviral agent in the treatment of herpes zoster and other viral infections. 5'-O-tert-Butyldimethylsilyl-D3-thymidine is a novel monophosphate, which can be activated to a diphosphate by either kinases or phosphoramidites. It has been shown to be effective against herpes virus and other DNA viruses that infect cells from various species. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

8-Bromoadenosine is a nucleotide that is structurally related to adenosine. It can be used as an inhibitor of guanine nucleotide-binding proteins and has shown biological properties in vitro. 8-Bromoadenosine has been shown to inhibit the mitochondrial membrane potential, cytosolic Ca2+, and the synthesis of RNA and protein. 8-Bromoadenosine also inhibits leukemia inhibitory factor (LIF) production by 3T3-L1 preadipocytes and induces apoptosis in T84 cells. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-Benzoyl-2'-deoxyadenosine is a nucleoside analog that is used in the diagnosis of infections caused by bacteria. N-Benzoyl-2'-deoxyadenosine binds to DNA duplexes and alters their structure, which can be detected using electrophoresis. N-Benzoyl-2'-deoxyadenosine has been shown to have low bioavailability and is insoluble in water, so it must be administered intravenously. It has also been found to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-Benzoyl-3'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine is a novel nucleoside analog that is structurally related to the natural nucleotide adenosine. N-Benzoyl-3'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine is an activator of ribonucleotide reductase, which converts ribonucleosides to deoxyribonucleosides. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-Benzoyl-5'-O-tert-butyldimethylsilyl-2'-deoxyadenosine serves as an intermediate in pharmaceutical synthesis.. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-Isobutyryl-5'-O-tert-butyldimethylsilyl-2'-deoxyguanosine can be used to activate proteins, receptors, and ion channels. It has been shown to bind to the receptor site on the cell membrane, which may inhibit the binding of ligands and then initiate signal transduction. N2-Isobutyryl-5'-o-(tert-butyldimethylsilyl)-2'-deoxyguanosine has been shown to inhibit protein interactions, such as antibody binding and peptide binding. This ligand also inhibits the activity of ion channels in a dose-dependent manner. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.