Nucleic Acids

N6-Methyladenosine is a modified form of adenosine that contains a methyl group at the N6 position and has a high importance in epigenetics. The result of this modification is specifically recognized mRNA in the cytoplasm which regulates mRNA stability. N6-Methyladenosine is made when a protein complex containin the writer enzyme METTL3 adds a methyl group to adenosine. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Trifluridine is an inhibitor of thymidine phosphorylase. TFT also inhibits thymidylate synthase (TS), a rate-limiting enzyme of DNA biosynthesis, and is incorporated into DNA. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-Deoxyuridine is an intermediate in the synthesis of thymidylate, which is a precursor for DNA synthesis. 2'-Deoxyuridine has been shown to inhibit the enzymatic activity of enzymes responsible for synthesizing uridine and thymidylate, leading to neuronal death. 2'-Deoxyuridine has been used as a fluorescence probe for nucleic acids and as a polymerase chain reaction (PCR) substrate. 2'-Deoxyuridine is also known to bind with toll-like receptor 4 (TLR4), which is involved in inflammatory responses. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-Deoxy-5-fluorocytidine is a methyltransferase inhibitor that inhibits the activity of DNA methyltransferases. 2'-Deoxy-5-fluorocytidine has been shown to inhibit the activity of DNA methyltransferases and also target histones and ribosomes, leading to tumor cell death. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2'-O-Methyluridine is an analog of uridine and has been shown to have antiviral and anticancer properties. 2'-O-Methyluridine inhibits protein synthesis by competing with uridine for the active site of the enzyme ribonucleotide reductase, which converts ribonucleotides to dNMPs. This compound also inhibits RNA synthesis by disrupting the pairing of adenine and cytosine residues in RNA strands. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

5-Fluoro-1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione has been shown to be a chemotherapeutic agent and is converted to 5-fluorouracil in the body, which inhibits cancer cell growth by inhibiting DNA synthesis and RNA synthesis. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

5-Bromo-2'-deoxyuridine is a nitrate reductase inhibitor that prevents the reduction of nitrate to nitrite by inhibiting the enzyme nitrate reductase. 5-Bromo-2'-deoxyuridine is a genotoxic agent that has been shown to cause DNA damage and cell death in vitro. 5-Bromo-2'-deoxyuridine also binds to NMDA receptors and may be useful as a model system for studying neurodegenerative diseases. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Tecadenoson is an analog of adenosine. Tecadenoson works by activating two types of receptors: A1 and A2A. Activation of these receptors leads to increased blood supply, which improves symptoms in patients with chronic obstructive pulmonary disease. Tecadenoson has also been shown to reduce inflammation and improve lung function in animal models of asthma. Tecadenoson is not active against bacterial infections or viral infections, but is effective against autoimmune diseases such as lupus erythematosus, rheumatoid arthritis, and vasculitis. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

2',3'-Isopropylideneuridine has been shown to inhibit binding of pestivirus inhibitors by monoclonal antibodies. 2',3'-Isopropylideneuridine was also found to inhibit the replication of human immunodeficiency virus (HIV) in tissue culture by binding to the viral RNA polymerase and inhibiting its activity, preventing viral replication. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.