Results for Nucleic Acids ( 3143 )
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Floxuridine is a nucleoside analog that inhibits the enzyme ribonucleotide reductase, which is involved in the synthesis of DNA. Floxuridine has been shown to inhibit tumor growth in animal models by inhibiting the production of reactive oxygen species and upregulating tumor suppressor genes, such as p53. It also has inhibitory effects on enzymes that are involved in cell proliferation, such as protein kinase C and tyrosine kinases. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Didanosine is a purine analog. Didanosine is an anti-retroviral drug used in the treatment of HIV in ART therapy, it also may increase acetaminophen related hepatotoxicity by enhancing mitochrondrial dysfunction. 2',3'-Dideoxyinosine has also been shown to inhibit the replication of other viruses such as herpes simplex virus type 1 and hepatitis B virus. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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2'-O-(2-Methoxyethyl)-cytidine is a cytidine derivative that can be used as a building block for crosslinking oligonucleotides. 2'-O-(2-Methoxyethyl)-cytidine is also used as a texturizing agent in food products. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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5-Fluoro-5’-deoxyuridine is a metabolite of the chemotherapeutic agent Capecitabine. 5-Fluoro-5’-deoxyuridine is an antimetabolite that inhibits the synthesis of DNA, RNA, and proteins by reversibly inhibiting ribonucleotide reductase. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Adenosine 5'-monophosphate disodium salt is a modified phosphoramidite used for the synthesis of deoxyribonucleosides and nucleosides. Adenosine 5'-monophosphate disodium salt is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). It may be used as a substrate by a variety of enzymes such as AMP-thymidine kinase, AMP deaminase and 5′-nucleotidase. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a beta-N9-glycosidic bond. Guanosine is present in the cerebrospinal fluid, intestinal cells, blood-brain barrier and in brain microvessels. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.
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2'-C-Methylcytidine is nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks viral production of HCV RNA and thus viral replication. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.